IDENTIFICATION OF PLANT SOURCES FROM NORTH ANDHRA PRADESH EXHIBITING IMMUNOMODULATORY ACTIVITY USING BALB/c MODELS

Authors

  • SHILPA VADLAMANI Department of Biotechnology, GITAM Institute of Science, GITAM University Visakhapatnam-530045, India
  • BALA DURGA DEVI K Department of Biotechnology, GITAM Institute of Science, GITAM University Visakhapatnam-530045, India
  • APARANJI POOSARALA Department of Biochemistry, Andhra University, Visakhapatnam-530003, India
  • VEERENDRA KUMAR BAPATLA Department of Biotechnology, GITAM Institute of Science, GITAM University Visakhapatnam-530045, India

Keywords:

Immunomodulatory, Terminalia chebula, Tylophora indica, Nycthathes arbor-tristis, Punica granatum, ELISA.

Abstract

In this present study, 10 different medicinal plants from north Andhra Pradesh were selected for the identification of potential immunomodulatory property using Balb/c mice. The aqueous leaf extract of Terminalia chebula (TC) Tylophora indica (TI), Nycthathes arbor-tristis (NA) and Punica granatum (PG) exhibited alleviated levels against OVA-specific IgG and IgM antibody responses as shown by enzyme-linked immune sorbent assay (ELISA). These plant sources have been further subjected to organic solvent extraction, chloroform (Chl), ethyl acetate (EA), and ethanol (Eth) for the purification of putative principles. The ethanolic fraction of these plants has been found to be having highest activity. The results obtained in this study shown that ethanol extracts of TC enhanced levels of IgG and IgM when compared to other solvent extracts.

Downloads

Published

31.03.2016

How to Cite

SHILPA VADLAMANI, BALA DURGA DEVI K, APARANJI POOSARALA, & VEERENDRA KUMAR BAPATLA. (2016). IDENTIFICATION OF PLANT SOURCES FROM NORTH ANDHRA PRADESH EXHIBITING IMMUNOMODULATORY ACTIVITY USING BALB/c MODELS. International Journal of Pharma and Bio Sciences, 7(1), 295–300. Retrieved from https://ijpbs.net/index.php/journal/article/view/4918

Issue

Volume 7, Issue 1, 2016

Section

Research Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.