PROTECTIVE ACTION OF PERGULARIA DAEMIA AND TERMINALIA CATAPPA ON CCL4 INDUCED HEPATOTOXICITY IN ALBINO RATS

Abstract

To investigate the hepatoprotective activity of the hydroalcoholic extracts of Pergularia daemia and Terminalia catappa on CCl₄ induced hepatotoxicity in wistar albino rats. The animals were grouped into seven with six rats in each group. Group I served as vehicle control, Group II served as Hepatotoxin treated group: (30% of CCl₄ - 1ml/kg,i.p.). Group III served as drug control :(30% of CCl₄ 1ml/kg ,i.p.) + (Silymarin- 25 mg/kg,,p.o.). Group IV,V served as pre treatment groups:  HAEPD(200 mg/kg ,p.o.)+30% CCl₄ and HAETC (200 mg/kg ,p.o.)+ 30% CCl₄. Group VI,VII served as Post-treatment groups:  30%CCl₄ + HAEPD and 30%CCl₄ +HAETC (200 mg/kg,p.o.) for the period of twenty five days. The biochemical parameters such as cholesterol,triglycerides, LDL,VLDL, Clotting time, urea ,uricacid, bilirubin creatinine were significantly increased (p<0.001)  in group II  animals. But the  Pre and Post treatment with hydroalcohol extracts of Pergularia daemia and  Terminalia catappa (200 mg /kg,p.o.) showed reduction of  cholesterol , triglycerides ,LDL,VLDL,Clotting time, urea ,bilirubin creatinine  and increased  the levels of RBC, Hb,PCV,HDL and protein profile. From this results it can be conclude that the groups treated with HAEPD and HAETC showed  hepatoprotective effects against CCl₄ induced liver damage in rats.