FORMULATION OPTIMIZATION OF TIZANIDINE HYDROCHLORIDE NANOPARTICLES USING 32 FACTORIAL DESIGNS

Authors

  • GUPTA RITU Invertis Institute of Pharmacy, Invertis University, Delhi Lucknow Highway, NH-24, Bareilly, Uttar Pradesh-243123, INDIA
  • BAJPAI MEENAKSHI Institute of Pharmaceutical Research, GLA University,17 Km Stone, NH-2, Mathura-Delhi Road, Chaumuhan, Mathura- Uttar Pradesh-281406,INDIA

Keywords:

Tizanidine hydrochloride (TIZ), 32 Factorial Design, Polymer amount (X1), Stabilizer concentration (X2)

Abstract

Tizanidine hydrochloride (TIZ) is a skeletal muscle relaxant which is used in the treatment of multiple sclerosis. The aim of this study was to prepare and optimize TIZ nanoparticles using 32 factorial design. The polymer amount (X1) and stabilizer concentration (X2) were selected as independent variables and their joint effects on the dependent variables viz. the size, the entrapment efficiency and the zeta potential of nanoparticles were studied. Design-Expert®8.0 software was used as a statistical tool to optimize the formulation design and investigate the effects of the formulation variables. A full model quadratic equation was obtained from multiple regression analysis. 3D surface and interaction plots were employed to graphically represent the effects of independent variables polymer amount (X1) and stabilizer concentration(X2) on the evaluation parameters size, entrapment efficiency and zeta potential of nanoparticles.

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Published

31.03.2016

How to Cite

GUPTA RITU, & BAJPAI MEENAKSHI. (2016). FORMULATION OPTIMIZATION OF TIZANIDINE HYDROCHLORIDE NANOPARTICLES USING 32 FACTORIAL DESIGNS. International Journal of Pharma and Bio Sciences, 7(1), 161–173. Retrieved from https://ijpbs.net/index.php/journal/article/view/4852

Issue

Volume 7, Issue 1, 2016

Section

Research Articles

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