SYNTHESIS OF NOVEL PYRAZOLINES BEARING TRICHLOROPHENYL MOIETY AS ANTIMICROBIAL AGENTS

Authors

  • LAXMANA K. Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka- 574 199.
  • SURESH P. NAYAK Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka- 574 199.
  • JAGADEESH PRASAD D. Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka- 574 199.
  • PRAKASH ANIL CASTELINO St Mary’s and Don Bosco Instituitions, Shirva, Udupi, Karnataka- 574 116.
  • KUMARA CHALUVAIAH Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka- 574 199.
  • SUCHETHA KUMARI Department of Biochemistry, K. S. Hegde medical Academy, Deralakatte, Karnataka- 574199.

Keywords:

Formylpyrazoline, Acetylpyrazoline, Antimicrobial Activity, Spectroscopic Data.

Abstract

In view of developing novel and effective antimicrobial agents, novel series of pyrazolines (4a-g and 5a-g) bearing 2,3,4-trichlorophenyl moiety were synthesized by treating 1-(2,3,4-trichlorophenyl)-3-(4-aryl)-2-propene-1-ones (3) with hydrazine hydrate and formic acid/ acetic acid (Schemes 1 and 2).  The newly synthesized compounds were characterized by elemental analysis and spectroscopic studies and screened for their in vitro antibacterial and antifungal activities. The screening studies revealed that the novel pyrazoline derivatives (4a-g and 5a-g) exhibited moderate to good activity.

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Published

31.03.2016

How to Cite

LAXMANA K., SURESH P. NAYAK, JAGADEESH PRASAD D., PRAKASH ANIL CASTELINO, KUMARA CHALUVAIAH, & SUCHETHA KUMARI. (2016). SYNTHESIS OF NOVEL PYRAZOLINES BEARING TRICHLOROPHENYL MOIETY AS ANTIMICROBIAL AGENTS. International Journal of Pharma and Bio Sciences, 7(1), 32–39. Retrieved from https://ijpbs.net/index.php/journal/article/view/4835

Issue

Volume 7, Issue 1, 2016

Section

Research Articles

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