Antioxidant Activity And Immunomodulatory Activity Of Pedalium Murex In Wistar Albino Rats

Abstract

Medicinal plants are a group of species that accumulate different active principles, useful in treating various human or animal diseases.  An important amount of therapeutic products are derived from medicinal plants (77% for cardiovascular diseases and 74% for digestive diseases).  Pedalium murex is a member of the sesame family, Pedaliaceae. It is found in different parts of the world such as tropical Africa, Srilanka, India, Mexico and Pakistan. The present study was carried out for the characterization, physical, chemical, microbial and immunological strength of the development of immune system for human era. The phytochemical compounds were analyzed. Twelve male Wister albino rats (200-220g) two months of age were used as experimental animals and were divided into four groups. In this animal model studies assessment of immunomodulatory activity was carried out by various hematological and serological tests like determine phagocytic activity and spleen weight.  In this study, different doses (100, 200 mg/kg body weight/day) of the ethanolic extract of the fruits showed significant activity and increased phagocytic response and spleen weight the result were compared with control and standard drug (septilin). The activity reported was dose dependent and set of data was analyzed using one-way analysis of variance (ANOVA) followed by Dunnett’s test Multiple Comparison test values **P<0.01 were considered significant. It has been concluded that the test extract possesses   promising immunostimulant or immune suppressive properties.