Influence Of Potassium Hyaluronate On The Change Of Phospholipase Activity And State Of The Membranes Of Damaged Somatic Nerves Of Rats

Abstract

It has been established that nerve injury is accompanied by an increase in the content of lysophospholipids and an increased activity both Ca^{2 +} - dependent and Ca^{2 +} - independent phospholipase A₂. The introduction of the drug enhances the regenerative processes in damaged nerve that is manifested in the restoration of orderliness of the membranes of nerve fibers, as well as in the reduction of lysophospholipids and activity of Ca^{2 +} - dependent phospholipase A₂. However, using the potassium hyaluronate does not lead to changes in the activity of Ca^{2 +} - independent phospholipase A₂ that likely indicates that Ca²⁺ - independent phospholipase A₂ is not involved in the mechanism of nerve regeneration. Thus, it can be assumed that the acceleration of regeneration processes in damaged nerve conductor under the action of potassium hyaluronate is likely mediated by the functioning of Ca²⁺ - dependent phospholipase A₂.