Computational Approaches To Study Dissolution Kinetics And Their Profiles Similitude Of Quetiapine Fumarate

Authors

  • RITU Department of Mathematics, Bioinformatics & Computer Applications , Maulana Azad National Institute of Technology (MANIT), Bhopal, Madhya Pradesh, INDIA
  • DR. USHA CHOUHAN Department of Mathematics, Bioinformatics & Computer Applications , Maulana Azad National Institute of Technology (MANIT), Bhopal, Madhya Pradesh, INDIA

Keywords:

Quetiapine Fumarate, Model dependent Approach, Model independent Approach, goodness of fit.

Abstract

In this paper the purpose was to describe the kinetics of drug dissolution of six different formulations and using different approaches to compare their dissolution profile. Model independent approaches, including the pair wise procedure, ratio test procedures  were used to characterize the drug dissolution profiles. Different mathematical models (zero order, first order, Higuchi model, Weibull model, Hixson Crowell, Korsmeyer-Peppas model) were applied to dissolution data of different formulations. The most appropriate model was chosen from the criteria goodness of fit based on R2, AIC.

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Published

31.12.2015

How to Cite

RITU, & DR. USHA CHOUHAN. (2015). Computational Approaches To Study Dissolution Kinetics And Their Profiles Similitude Of Quetiapine Fumarate. International Journal of Pharma and Bio Sciences, 6(4), 94–100. Retrieved from https://ijpbs.net/index.php/journal/article/view/4686

Issue

Volume 6, Issue 4, 2015

Section

Research Articles

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