Alterations In Lipid Content In Mancozeb Induced Albino Mice

Abstract

The histochemical effects of the lipid and the biochemical analysis of cholesterol content induced by mancozeb, a widely used fungicide in India and in Madhya Pradesh were observed on Swiss albino mice (Mus musculus albinicus). Three groups were used for the present experiment, where Group I was taken as control and was administered distilled water. Group II and III were the test groups receiving mancozeb at a dose of 4.2 mg/kg bw and 6.7 mg/kg bw respectively for 4 weeks. Thereafter, the histochemical analysis of lipid using Sudan Black III stain in liver and kidney tissues was performed which revealed normal lipid content in the control (Group I), while   increase in the  lipid content was noted in both Group II and Group III. The biochemical analysis of the total serum cholesterol level also showed increase in the treated groups as compared to the control group. This study indicates marked alteration in the lipid content in mancozeb exposed albino mice.