EVALUATION OF TOXICITY OF CROCUS SATIVUS (SAFFRON) DURING EMBRYOGENESIS IN WISTAR RATS

Authors

  • RAMESH EDAMULA Department of Safety Assessment, Advinus Therapeutics Limited, Peenya II Phase, Bengaluru - 560058, India
  • M.DEECARAMAN Department of Biotechnology, Dr.M.G.R Educational and Research Institute, Maduravoyal, Chennai - 600 095, India
  • M.VIJAYALAKSHMI Department of Biotechnology, Dr.M.G.R Educational and Research Institute, Maduravoyal, Chennai - 600 095, India
  • D.P.SANTHOSH KUMAR Department of Safety Assessment, Advinus Therapeutics Limited, Peenya II Phase, Bengaluru - 560058, India
  • H.KRISHNAPPA Department of Safety Assessment, Advinus Therapeutics Limited, Peenya II Phase, Bengaluru - 560058, India

Keywords:

Saffron, Malformations, Fetus, Albino rats, Food additive

Abstract

Crocus sativus (saffron) is widely used as a food additive and as active components in many traditional medicine and modern pharmacology. Saffron is generally considered as a safe food additive and medicinal agent. However many studies carried out using pregnant mice have shown that saffron causes intrauterine growth retardation and induces embryonic malformations. Hence the present study was aimed to evaluate if a similar effect is seen in pregnant albino rats. In our experiment no deleterious effects were noted in the pregnant dams or on the fetuses up to the level of 500 mg/kg body weight dose.

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Published

31.12.2015

How to Cite

RAMESH EDAMULA, M.DEECARAMAN, M.VIJAYALAKSHMI, D.P.SANTHOSH KUMAR, & H.KRISHNAPPA. (2015). EVALUATION OF TOXICITY OF CROCUS SATIVUS (SAFFRON) DURING EMBRYOGENESIS IN WISTAR RATS. International Journal of Pharma and Bio Sciences, 6(4), 717–722. Retrieved from https://ijpbs.net/index.php/journal/article/view/4660

Issue

Volume 6, Issue 4, 2015

Section

Research Articles

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