PHARMACOKINETIC STUDIES OF GEMCITABINE LOADED PLGA NANOPARTICLES IN ANIMAL MODEL

Abstract

The Gemcitabine loaded PLGA nanoparticles were prepared by modified nanoprecipitation method, to improve the bioavailability of the drug in brain. The nanoparticular formulation was characterized for particle size analysis, encapsulation efficiency, zeta potential and in vitro release study.  The pharmacokinetic studies of Gemcitabine-loaded PLGA nanoparticles were carried out in Sprague Dawley rats. The study revealed C_max and T_max were significantly altered and clearance was less in brain and blood when compared to that of plain Gemcitabine solution. These results suggested that PLGA nanoparticles had considerably increased the transport of Gemcitabine across the blood brain barrier (BBB).