MOLECULAR DOCKING STUDIES OF TETRAZOLE DERIVATIVES ON COX-2 PROTEIN RESIDUE

Authors

  • R. ARULMOZHI Department of Chemistry, Faculty of Engineering and Technology, SRM University, Kattankulathur-603 203, India.
  • HELEN P. KAVITHA Department of Chemistry, SRM University, Ramapuram, Chennai-600089, Tamil Nadu, India
  • N.ABIRAMI Department of Chemistry, Faculty of Engineering and Technology, SRM University, Kattankulathur-603 203, India.
  • R.ARUL MURUGAN Department of Chemistry, SRM University, Ramapuram, Chennai-600089, Tamil Nadu, India

Keywords:

Inflammation, Tetrazoles, paw oedema method, Indomethacine, COX-2protein.

Abstract

Tetrazoles are the hetrocyclic compounds having diverse biological activities such as analgesic, anti-inflammation, antimicrobial, anticancer, antidiabetic etc., and an impending source in biosciences. Invivo analysis was carried out on anti-inflammatory property of synthesized five tetrazole derivatives (a, b, c, e and g) which revealed that the compound(g) exhibited potential anti-inflammatory activity of 49% when compared to standard Indomethacine at10µg/ml in the previous report by the authors.In the present investigation, molecular docking studies were performed for the above tetrazole derivatives to evaluate the in- silico anti-inflammatory activity against Cycloxigenase-2 (COX-2) protein as model compound and the data was compared with Indomethacine

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Published

31.12.2015

How to Cite

R. ARULMOZHI, HELEN P. KAVITHA, N.ABIRAMI, & R.ARUL MURUGAN. (2015). MOLECULAR DOCKING STUDIES OF TETRAZOLE DERIVATIVES ON COX-2 PROTEIN RESIDUE. International Journal of Pharma and Bio Sciences, 6(4), 522–529. Retrieved from https://ijpbs.net/index.php/journal/article/view/4642

Issue

Volume 6, Issue 4, 2015

Section

Research Articles

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