SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA BINDING STUDIES OFDINUCLEAR COPPER (II) COMPLEXES WITH 1, 10-PHENANTHROLINE

Authors

  • S. CHANDRASEKHAR Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu – 515003
  • B. MOKSHARAGNI Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu – 515003
  • K. HUSSAINREDDY Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu – 515003

Keywords:

Synthesis, dinuclear copper(II) complexes, 1,10-phenanthroline, spectral studies, DNA binding studies.

Abstract

The mononuclear copper(II) complex, Cu(phen)(H2O)(NO3)2 (1) has been obtained by the reaction of 1,10-phenanthroline with Cu(NO3)2.3H2O in methanol solution .The complex reacts with mono anionic ligands Cl-, Br-, I- and CH3O- in methanolic solution to form the stable binuclear complexes [Cu(phen)(µ-X)(H2O)]2 (NO3)2. Where,  X = Cl-(2), Br- (3), I- (4), and CH3O- (5). These complexes were characterized by electronic, IR, ESR, magnetic moments and conductivity measurements.  The electrochemical behaviour of these complexes has been investigated by using cyclicvoltammetry. The interactions of these complexes with calf thymus DNA were investigated using absorption spectrophotometry. Electronic absorption data suggest that the complexes bind DNA via intercalation.

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Published

31.12.2015

How to Cite

S. CHANDRASEKHAR, B. MOKSHARAGNI, & K. HUSSAINREDDY. (2015). SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA BINDING STUDIES OFDINUCLEAR COPPER (II) COMPLEXES WITH 1, 10-PHENANTHROLINE. International Journal of Pharma and Bio Sciences, 6(4), 25–39. Retrieved from https://ijpbs.net/index.php/journal/article/view/4592

Issue

Volume 6, Issue 4, 2015

Section

Research Articles

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