Clinical and Biochemical Parameters in Relation to Serum LP(A) Levels in Indian Children and Adolescents

Abstract

The incidence of obesity, type 2 diabetes and cardiovascular diseases among childhood in India is largely increasing. The serum Lp(a) and its correlation with biochemical, clinical and anthropometric parameters were evaluated in 338 children and adolescents (Controls-103, obese-96, Overweight-97, Congenital heart disease42) of age group between 10 – 17 years. The levels of serum Lp(a) were measured by Latex Immunoturbidimetry method. Serum Lp(a) levels were found to be significantly elevated in obese, overweight and congenital heart disease children than controls. Serum Lp(a) levels showed positive correlation with BMI, WHR, TC, TG, LDL-C, TCHR and no association with fasting glucose, HDL-C, systolic and diastolic blood pressure. Our  findings suggest that Lp(a) levels are genetically determined, not related to gender differences and sexual maturation. Childhood obesity is associated with lipid patterns. Therefore, it has been suggested that physical activity in overweight and obese children is associated with significant changes in Lp(a) levels.