THERAPEUTIC POTENCY OF GREEN TEA EXTRACT ON NEUROCHEMICAL AND OXIDATIVE CHANGES CORRELATES TO AUTISTIC DISORDER IN RAT PUPS MODEL.

Authors

  • FATMA ELZAHRAA H. SALEM Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt

Keywords:

Autism, Valproate, Green tea extract, Catecholamine, Amino acids, Brain.

Abstract

Prenatal exposure to valproate is capable of inducing experimental autism in rat
pups. This study aimed to investigate the role of green tea extract in ameliorating the
toxicity induced by autism. Pregnant rats were treated with a single intraperitoneal
dose of sodium valproate (600mg/kg) on 12.5thgestational day. The treatment with
green tea extract started orally in autistic rat pups at postnatal day 15 for 20 days
(300mg/kg). Induction of autism resulted in a significant decrease in cerebellum and
cortical 5-HT, DA, NE, GABA, glycine and taurine and decrease in brain cholesterol
and glutathione at P<0.05. However, it showed significant increase in glutamate,
aspartate, serine and lipid peroxidation. Treatment with green tea extract showed
significant improvement in most of the studied parameters at P<0.05. In conclusion, it
could be stated that green tea extract exerts ameliorative effect on autistic rat pups
possibly due to antioxidant action and could be effective in the management of
autism.

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Published

30.09.2015

How to Cite

FATMA ELZAHRAA H. SALEM. (2015). THERAPEUTIC POTENCY OF GREEN TEA EXTRACT ON NEUROCHEMICAL AND OXIDATIVE CHANGES CORRELATES TO AUTISTIC DISORDER IN RAT PUPS MODEL. International Journal of Pharma and Bio Sciences, 6(3), 757–766. Retrieved from https://ijpbs.net/index.php/journal/article/view/4520

Issue

Volume 6, Issue 3, 2015

Section

Research Articles

Categories

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