Anti-Tubercular Activity Of Fluoro Benzothiazole Comprising Potent Thaizolidinone

Authors

  • B.S. SATHE Research Scholar (Jawaharlal Nehru Technological University, Hyderabad),
  • E. JAYCHANDRAN Department of Pharmaceutical Analysis, Smt. S. S. Patil College of Pharmacy, Chopda – 425 107
  • V. A. JAGTAP Department of Pharmaceutical Analysis, Smt. S. S. Patil College of Pharmacy, Chopda – 425 107
  • G.M SREENIVASA P. G. Department of Pharmaceutical Chemistry, S. C. S. College of Pharmacy, Harapanahalli – 583 131

Keywords:

Antitubercular activity, Fluorobenzothiazole, Thiazolidinone.

Abstract

4-Fluoro-3-chloroanilline treated with Potassium thiocyanate in presence of Glacial acetic acid and bromine was converted into 2-amino-6-fluoro-7-chlorobenzothiazole. The synthesized compound in presence of m-nitro benzaldehyde refluxed in ethanol to obtained 3-[6'-fluoro-7'-chloro(1',3') benzo thiazol-2'-yl]-m-nitrophenyl(1,3) thiazolidine-4-one. The above said compound was treated with ortho, meta and para nitroanillines, ortho, meta, para chloroanillines, morpholino, Piperazine, diphenylamine in the presence of DMF to obtain different derivatives. Some compounds showed promising antimycobacterial activity. 

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Published

31.12.2010

How to Cite

B.S. SATHE, E. JAYCHANDRAN, V. A. JAGTAP, & G.M SREENIVASA. (2010). Anti-Tubercular Activity Of Fluoro Benzothiazole Comprising Potent Thaizolidinone. International Journal of Pharma and Bio Sciences, 1(4), 495–500. Retrieved from https://ijpbs.net/index.php/journal/article/view/452

Issue

Volume 1, Issue 4, 2010

Section

Research Articles