Synthesis and Antimicrobial Activity of Alkyl-2-{[3-(3'-Chloro-4'-Nitrophenyl)-2-Oxo-3, 4-Dihydro-2h-1, 3, 2l5-Benzoxazaphosphinin-2-Yl]Amino} Alkanoates

Authors

  • K.SURESH KUMAR Department of Chemistry, S.V.University, Tirupati 517 502, India.
  • N.BAKTHAVATCHALA REDDY Department of Chemistry, S.V.University, Tirupati 517 502, India.
  • K. UMA MAHESWARA RAO Department of Chemistry, S.V.University, Tirupati 517 502, India.
  • SK.ANNAR Department of Chemistry, S.V.University, Tirupati 517 502, India.
  • C.SURESH REDDY Department of Chemistry, S.V.University, Tirupati 517 502, India.

Keywords:

1,3,2-benzoxazaphosphinine, 2-[(3'-chloro-4'-nitrophenylamino)methyl] phenol, aminoacid ester, antimicrobial activity.

Abstract

Synthesis of alkyl-2-{[3-(3'-chloro-4'-nitrophenyl)-2-oxo-3,4-dihydro-2H-1,3,2λ5-benzoxazapho sphinin- 2-yl]amino} alkanoates (4a-j) were accomplished via a two-step process, involving the condensation of 2-[(3'-chloro-4'-nitrophenyl amino)methyl]phenol (1) with phosphorusoxychloride in the presence of triethylamine (TEA) in dry tetrahydrofuran (THF) to produce the corresponding monochloride intermediate (2), and subsequent reaction with the amino acid alkyl ester in dry THF in the presence of TEA at various temperatures. These compounds were characterized by IR, 1H, 13C, 31P NMR and mass spectral data and all them exhibited significant antibacterial and fungal activity

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Published

30.06.2010

How to Cite

K.SURESH KUMAR, N.BAKTHAVATCHALA REDDY, K. UMA MAHESWARA RAO, SK.ANNAR, & C.SURESH REDDY. (2010). Synthesis and Antimicrobial Activity of Alkyl-2-{[3-(3’-Chloro-4’-Nitrophenyl)-2-Oxo-3, 4-Dihydro-2h-1, 3, 2l5-Benzoxazaphosphinin-2-Yl]Amino} Alkanoates. International Journal of Pharma and Bio Sciences, 1(2), 1–7. Retrieved from https://ijpbs.net/index.php/journal/article/view/448

Issue

Volume 1, Issue 2, 2010

Section

Research Articles