FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING HOLLOW MICROSPHERE (MICROBALLON) LOADED WITH ACYCLOVIR

Abstract

The present study deals with the formulation of gastroretentive hollow microsphere of Acyclovir using Eudragit RS 100 & Ethyl cellulose as a polymer  & solvent (Ethanol & Di chloro methane) in different ratio of solvent evaporation method. A number of evaluation parameter was carried out. A drug – exicipient compatibility studies was performed by FTIR. Microspheres were evaluated for particle size, micromeritic properties, flow property, drug entrapment efficiency, in vitro drug release , kinetic studies. The shape & size of microsphere were carried by Scanning Electron Microscopy.