SYNTHESIS, SPECTRAL CHARACTERIZATION AND EVALUATION OF INVITRO ANTIBACTERIAL ACTIVITY OF ISONICOTINOYL HYDRAZONES BEARING PYRIDINE MOIETY

Authors

  • B. MOKSHARAGNI Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu- 515 003, AP, India
  • KANDERI DILEEP KUMAR Department of Microbiology, Sri Krishnadevaraya University, Anantapuramu- 515 003, AP, India
  • S. CHANDRASEKHAR Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu- 515 003, AP, India
  • K. HUSSAIN REDDY Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu- 515 003, AP, India

Keywords:

Synthesis, characterization, isonicotinoyl and nicotinoylhydrazones, antibacterial activity.

Abstract

Isonicotinoyl and nicotinoyl hydrazones bearing pyridine moiety have been synthesized by simple condensation reaction  between carbonyl compounds(1-3)  viz. 2-formyl pyridine, 2-acetylpyridine,  2- benzoylpyridine and isonicotinic acid  hydrazide (4)/nicotinic acid  hydrazide(5).  All the hydrazones are thoroughly characterized by IR, 1H- NMR  and  mass spectral  data. Syntheses of these compounds are further confirmed by mass spectrometry. All the compounds (6-11)  were  screened for their anti-bacterial activities  against    Staphylococcus   aureus,   Bacillus subtilis,  Escherichia coli  and Salmonella typhi . Isonicotinoyl  hydrazones show more antibacterial  activity  than  the corresponding nicotinoyl  hydrazones.  Substituent  groups  -H,  -CH3  and  C6H5  groups of azomethine  carbon are  varied. The  hydrazones   having  a methyl  group  attached   to  azomethine carbon atom  show more  pronounced activity.   

Downloads

Published

30.09.2015

How to Cite

B. MOKSHARAGNI, KANDERI DILEEP KUMAR, S. CHANDRASEKHAR, & K. HUSSAIN REDDY. (2015). SYNTHESIS, SPECTRAL CHARACTERIZATION AND EVALUATION OF INVITRO ANTIBACTERIAL ACTIVITY OF ISONICOTINOYL HYDRAZONES BEARING PYRIDINE MOIETY. International Journal of Pharma and Bio Sciences, 6(3), 11–18. Retrieved from https://ijpbs.net/index.php/journal/article/view/4373

Issue

Volume 6, Issue 3, 2015

Section

Research Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.