DETECTION OF DRUG RESISTANCE IN ENTEROBACTERIACEAE ISOLATES FROM DIABETIC FOOT ULCER

Abstract

Diabetic Foot ulcer (DFU) is an infection, ulcer or destruction of deep tissue, associated with neurological abnormalities and various degrees of peripheral vascular disease of lower limb, collectively known as the diabetic foot syndrome. Foot ulceration and amputation are economically most expensive diabetic complications. Diabetic foot infection is poly-microbial in nature, many studies have reported on the bacteriology of DFU over 30 years, but the results varied with different places. The present study was aimed to characterize the enterobacteriaceae isolates from diabetic foot ulcer. 123 DFU pus samples were collected from tertiary care hospital Chennai. 56 isolates were found to be enterobacteriaceae isolates among these 97 gram negative isolates. Enterobacteriaceae showed wide range of resistance to many of the drugs tested. imipenem, cephotaxime and cefepime showed 25 % (14/56), 60.07% (34/56) and 55.36% (31/56) of resistance respectively. ESBL positivity showed 76.78% (43/56). Whereas aztreonam, and trimethoprim showed higher percentage of resistance 85.71%, and 75% respectively. A detailed knowledge of the susceptibility to antimicrobial agents is necessary to facilitate the development of effective strategies to treat diabetic foot infections, especially the ESBL infections.