COMPARITIVE EVALUATION OF JATROPHA CURCAS LEAVES EXTRACT FOR ANTIBACTERIAL, ANTI-AVIAN INFLUENZA A VIRUS (H5N1) PROPERTIES AND GC-MS PROFILE

Authors

  • F.K. EL-BAZ Plant Biochemistry Dept., National Research Centre (NRC), Dokki, Cairo, Egypt.
  • O. BAGATO Center of Scientific Excellence for influenza viruses, National Research Centre (NRC), Dokki, Cairo,Egypt.
  • H.F. ALY Therapeutic Chemistry Dept., National Research Centre (NRC), Dokki, Cairo, Egypt.
  • S A. SAAD Plant Biochemistry Dept., National Research Centre (NRC), Dokki, Cairo, Egypt.
  • M.A. ALI Center of Scientific Excellence for influenza viruses, National Research Centre (NRC), Dokki, Cairo,Egypt.
  • A.A. MOHAMED Plant Biochemistry Dept., National Research Centre (NRC), Dokki, Cairo, Egypt.

Keywords:

Antiviral; H5N1; food borne pathogens; GC-MS; J. curcas; phytoconstituents.

Abstract

The potent antibacterial and antiviral activity of petroleum ether, ethyl acetate, successive and crude methanolic extracts of J. curcas leaves was evaluated. The antibacterial activity of J. curcas extracts was studied against 6 common foods borne bacteria using disc diffusion assay. The antibacterial activity of J. curcas extracts showed different degrees of inhibition zone against the pathogens bacteria. Yet, successive methanolic and ethyl acetate extracts were effective against most of the tested strains. Additionally, all J. curcas extracts were evaluated against the highly pathogenic H5N1 influenza virus (A/chicken/Egypt/M7217B/2013 (H5N1)) using plaque reduction assay. Crude methanolic extract showed antiviral activity with virucidal effect of 75% at concentration 25 µg/µl. The GC-MS analysis of petroleum ether and ethyl acetate extracts revealed the presence of major active constituents. The present study may suggest the possibility for developing new antibacterial and antiviral compounds from J. curcas leaves.

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Published

30.06.2015

How to Cite

F.K. EL-BAZ, O. BAGATO, H.F. ALY, S A. SAAD, M.A. ALI, & A.A. MOHAMED. (2015). COMPARITIVE EVALUATION OF JATROPHA CURCAS LEAVES EXTRACT FOR ANTIBACTERIAL, ANTI-AVIAN INFLUENZA A VIRUS (H5N1) PROPERTIES AND GC-MS PROFILE. International Journal of Pharma and Bio Sciences, 6(2), 108–120. Retrieved from https://ijpbs.net/index.php/journal/article/view/4208

Issue

Volume 6, Issue 2, 2015

Section

Research Articles

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