SALVIA OFFICINALIS OIL IMPROVES THE ATHEROGENIC INDEX AND CARDIOTOXICITY IN ALBINO RATS TREATED WITH 5- FLUOROURACIL

Abstract

5-Fluorouracil is reported as the second most common chemotherapeutic agent after anthracyclines causing cardiotoxicity. Thirty male albino rats were divided into three groups. Rats in group I received saline daily for 8 days only and served as the control. Rats in group II received saline orally for 8 days, then administrated with 5-Fluorouracil (150mg\\ kg B.W\\once I.P injection at the 5^th day). Rats in group III were orally dosed with Salvia. officinalis oil (0.4ml\\ kg B.W\\day) for 8 days and  at the 5^th day, were administrated with the same previous dose of 5-Fluorouracil. 5-Fluorouracil induced a significant increase in serum concentrations of cTnI, CK-MB and MDA concentration in cardiac homogenate. 5-Fluorouracil significantly decreased GSH concentration in cardiac homogenate and altered serum lipid profile. Its administration also resulted in release of some inflammatory markers such as IL-1β and myeloperoxidase. Salvia officinalis oil pre-co-post-treatment ameliorated the altered parameters caused by 5-Fluorouracil induced cardiotoxicity in rats.