EVALUATION OF ANALGESIC ACTIVITY OF ETHANOLIC EXTRACT OF CANANGA ODORATA LAM IN EXPERIMENTAL ANIMALS

Abstract

The present study evaluates the central and peripheral analgesic activity of ethanolic extract of Cananga Odorata Lam [EECO] in experimental animals.Acute toxicity test was done following OECD guidelines. EECO (100mg/kg, 200mg/kg and 400mg/kg b.w. p.o) was evaluated for central and peripheral analgesic activity by the Tail flick method in wistar rats and 0.7%acetic acid induced Writhing test in Swiss albino mice respectively. Aspirin was used as the standard drug in the dose of 300 mg/kg b.w. in tail flick method and 100 mg/kg b.w. in acetic acid induced writhing test.   EECO significantly increased the reaction time in tailflick method(p<0.01) at all the doses and decreased the number of writings in Writhing test (p<0.01) at all the doses.EECO has significant central and peripheral analgesic activity.