AN OPEN LABELED, SINGLE CENTRE, PROSPECTIVE, CLINICAL STUDY TO EVALUATE EFFICACY AND SAFETY OF ARWL12 CAPSULE IN PATIENTS SUFFERING FROM INTERNAL HEMORRHOIDS

Abstract

Hemorrhoid is abnormal dilatation of venous plexus of anus, which causes bleeding per rectum, pain and itching at anus. ‘ARWL12’ capsule is a polyherbal formulation has been evaluated for efficacy and safety in patients of internal hemorrhoids. Thirty two patients received two ‘ARWL12 capsules’, twice daily orally after meals for 60 days. On day 60, reduction in proportion of patients showing bleeding per rectum was observed. The episodes and quantity of bleeding per rectum and piles mass decreased at the end of the study. The quality of life of patient also improved significantly. Global evaluation by physician and patient showed excellent improvement in reducing the symptoms of hemorrhoids. Almost all patients of the study showed excellent tolerability to study drug. No significant changes, in most of the safety laboratory parameters were observed. The study provided good evidence for potential efficacy and safety of ‘ARWL12’ capsule in patients with internal hemorrhoids.