ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF ERYNGIUM FOETIDUM LINN.

Abstract

Analgesic activity of Aqueous extract of Eryngium foetidum (AEEF) was evaluated in a.) Acetic acid induced writhing model in albino mice b.) Tail-flick method in albino rats. Animals were divided into 5 groups of 6 animals each. Group I (control), group II (standard), group III, IV & V (AEEF 200 mg/kg, 400 mg/kg & 800 mg/kg p.o). In acetic acid induced writhing model, with Aspirin 100 mg/kg as standard, 15min after drug administration, writhing was induced by giving 3% acetic acid i.p. Total no. of writhes were counted for 20 minutes and percentage protection calculated. In Tail-flick method, with Pethidine (5mg/kg i.p.) as standard, reaction time of the animals was assessed by analgesiometer at 30, 60, 120 minutes. AEEF significantly reduced (p<0.05) acetic acid induced writhing. In tail flick model, AEEF produced significant increase in reaction time (p<0.05).