ANTIMICROBIAL, ANTIFUNGAL AND ANTIDIABETIC PROPERTIES OF CLERODENDRUM INFORTUNATUM

Abstract

Clerodendrum infortunatum leaves extract have been studied for their potential antibacterial, antifungal, free radical scavenging, α amylase and α glucosidase activity. The properties of ethanol and chloroform extracts were analyzed by in-vitro techniques. The antimicrobial activity of C.infortunatum was performed by disc diffusion method in which  the ethanol extract was exhibited significant antibacterial activity against Bacillus subtillis (12.00mm), Aeromonas hydrophila (4.67 mm), Shigella boydii (10.67 mm), Escherichia coli (8.00 mm) and Staphylococcus.aureus (10.00 mm), and antifungal activity against Trichophyton mentagrophytes (9.00mm), Fusarium oxysporum (13.00mm), Penicillium chrysogenum (11.34mm), Aspergillus  niger (14.67mm) and Aspergillus flavus (7.34mm). The qualitative analysis of photochemical showed the presence phenolics, alkaloids, flavonoid, saponin, tannin and anthraquinone on both ethanolic and chloroform extracts. Furthermore, to evaluate α-amylase and α-glucosidase inhibitory effect of C. infortunatum extracts, the extracts were subjected to in-vitro inhibition studies with the enzymes α-amylase and α-glucosidase. The ethanolic extract of C.infortunatum showed high inhibition in both α-amylase (17.25%) and α-glucosidase activities. The results provided a platform for the use of C. infortunatum for therapeutics.