New Titrimetric Estimation of Naproxen Bulk Drug Sample using Ibuprofen Sodium as Hydrotropic Solubilizing Agent

Authors

  • R.K.MAHESHWARI 1Department of Pharmacy, Shri G.S. Institute of Technology and Science Indore – 452003, India.
  • NARENDRA GOVIL 1Department of Pharmacy, Shri G.S. Institute of Technology and Science Indore – 452003, India.
  • MAYANK RAI Department of Pharmacy, Shri G.S. Institute of Technology and Science Indore – 452003, India.
  • MITHUN SINGH RAJPUT College of Pharmacy, IPS Academy, Knowledge Village, Rajendra Nagar, A.B.Road, Indore- 452012, India.

Keywords:

Hydrotropy, Naproxen, Ibuprofen sodium, Titrimetry and Solubility enhancement.

Abstract

In solubility determination, it was found that there is tremendous increase in solubility of naproxen in hydrotropic 0.5 M ibuprofen sodium solution. In the present investigation, solution of 0.5 M ibuprofen sodium (an economic hydrotropic agent) has been employed to solubilize a poorly water soluble drug naproxen for its titrimetric analysis. The results of analysis by proposed method are very comparable with those of British Pharmacopoeial method. The proposed method is new, rapid, simple and reproducible. The proposed method of analysis does not involve the use of an organic solvent, hence it is eco-friendly and safe method.

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Published

31.03.2010

How to Cite

R.K.MAHESHWARI, NARENDRA GOVIL, MAYANK RAI, & MITHUN SINGH RAJPUT. (2010). New Titrimetric Estimation of Naproxen Bulk Drug Sample using Ibuprofen Sodium as Hydrotropic Solubilizing Agent. International Journal of Pharma and Bio Sciences, 1(1), 1–3. Retrieved from https://ijpbs.net/index.php/journal/article/view/41

Issue

Volume 1, Issue 1, 2010

Section

Research Articles