ANALYSIS OF IMMUNE RESPONSES IN MICE EXPOSED TO ACACIA NILOTICA

Abstract

In the present study the immune response level and various immunological properties in experimental mice was assessed after administering various extracts of A. nilotica and immunosuppressive drugs. The ethanol extract of A. nilotica showed highest antibody titre (7 log₂²) followed by hexane and chloroform extract (6 log₂²) and butanol and water extract (5.5 log₂²). The increment in ‘B’ lymphocyte number was much pronounced in mice by the administration of A. nilotica in combination with immunoenhansive drug than the lone effect of immunoenhansive drug. B cell decrement was pronounced in mice treated with immunosuppressive drug while a moderate decrement was noticed due to A. nilotica in combination with immunosuppressive drug. The increment in blood cell counts was much pronounced in mice by the administration of A. nilotica in combination with immunoenhansive drug than the lone effect of immunoenhansive drug. The increment in ‘T’ cell count may be due to the impact of plant drug on the synthesis, proliferation and activation of ‘T’ cells in treated animals.