Formulation And Evaluation Of Rifampicin And Gatifloxacin Niosomes On Logarithmic-Phase Cultures Of Mycobacterium Tuberculosis

Authors

  • N.PAVALA RANI Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli-620 021
  • T.N.K.SURIYAPRAKASH Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli-620 021
  • R.SENTHAMARAI Department of Pharmaceutics, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli-620 021

Keywords:

Niosomes, Rifampicin, Gatifloxacin, BACTEC, Mycobacterium tuberculosis.

Abstract

Niosomes are vesicles mainly consisting of non-ionic surfactants that encloses and encompasses the drug molecules. Niosomes of rifampicin and gatifloxacin were prepared by lipid hydration technique using rotary flash evaporator. The prepared rifampicin and gatifloxacin niosomes showed a vesicle size in the range of 100-300nm, the entrapment efficiency were 73% and 70% respectively. The invitro release study showed that 98.98% and 97.74% of release of rifampicin and gatifloxacin niosomes respectively. The bactericidal activities of the niosomal formulation were studied by BACTEC radiometric method using the resistant strains (RF 8554) and sensitive strains (H37Rv) of Mycobacterium tuberculosis which showed greater inhibition and reduced growth index. 

Downloads

Published

31.12.2010

How to Cite

N.PAVALA RANI, T.N.K.SURIYAPRAKASH, & R.SENTHAMARAI. (2010). Formulation And Evaluation Of Rifampicin And Gatifloxacin Niosomes On Logarithmic-Phase Cultures Of Mycobacterium Tuberculosis. International Journal of Pharma and Bio Sciences, 1(4), 379–387. Retrieved from https://ijpbs.net/index.php/journal/article/view/404

Issue

Volume 1, Issue 4, 2010

Section

Research Articles