PREVALENCE OF MRSA AND MSSA INFECTION IN DIABETIC FOOT ULCER

Abstract

This study investigated the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin sensitive Staphylococcus aureus in infected diabetic foot ulcers of 100 patients. Pus samples were collected and they were cultured by using appropriated methods.  The S. aureus was the most common pathogen among the Gram-positive bacteria isolated from ulcers. Of the 65 Staphylococcus aureus isolated, 50 (76.92%) were found to be Methicillin resistant (MRSA) and 15 (23.07%) were Methicillin sensitive (MSSA). Methicillin resistance Staphylococcus aureus were tested for vancomycin resistance. It was concluded that patients with diabetes for long duration (more than 10-15 yrs) with high blood sugar level (350-450mg/dl) were predominantly affected and the foot ulcers were significantly higher in males (80%). The Methicillin resistance Staphylococcus aureus (MRSA) was sensitive to vancomycin and imipenem antibiotics and the minimum inhibitory concentration (MIC) of vancomycin for MRSA is 0.01mg concentration and MIC of methicillin for MSSA is 60 mg concentration.