A STUDY OF THE PATTERN OF INSULIN RESISTANCE IN EUGLYCEMIC OFFSPRINGS OF DIABETIC PARENTS AND COMPARISION WITH AGE, SEX MATCHED CONTROLS AMONG SOUTH INDIAN POPULATION.

Abstract

To study the pattern of insulin resistance among euglycemic offspring of diabetic parents by appropriately matching for sex, and age in controls. Using inclusion & exclusion criteria 52 euglycemic offspring as subjects and 25 controls were taken. FBS, PPBS, Fasting insulin levels and Insulin resistance were calculated by HOMA-IR method. The results were tabulated and studied. siblings of diabetic parents had higher levels of fasting insulin level, insulin resistance when compared to the controls with a P value of 0·001 and 0·00 respectively. The sub group analysis among the male, female offspring also showed similar results and an additional finding was that female offspring of diabetic fathers had a higher IR when compared to the other groups.There is significant association between parental diabetic status and onset of insulin resistance in offspring when compared to the controls.