ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF ESCHERICHIA COLI ISOLATES CAUSING URINARY TRACT INFECTIONS AT TERTIARY CARE HOSPITAL.

Abstract

Escherichia coli is the most common organism causing both community as well as hospital acquired UTI. The antibiotic resistance has increased over the past many years. Hence we aimed to assess the current antibiotic resistance pattern in the common uropathogen E.coli from urine samples from in and out patients at VIMS, Bellary, presenting with UTI. Mid-stream urine samples were processed for routine microscopy and culture and the pathogens isolated were identified by standard methods. Antibiotic susceptibility was done by Kirby Bauer disc diffusion method. A total of 2,024 urine samples collected from patients of suspected UTIs, 812 samples showed growth. E.coli was the predominant urinary pathogen (53.2%) followed by Klebsiella spp(19%), Pseudomonas spp(10.8%).Escherichia coli showed high resistance to Amoxycillin (82.4%), Amoxicillin-clavulanic acid (80.78%) and Ciprofloxacin(78%). The present study shows E.coli to be the most common isolate. The pathogens are multidrug resistant with only few available options like Amikacin, Nitrofurantoin and PiperacillinTazobactum. Increasing antibiotic resistance trends indicate that it is imperative to rationalize the use of antimicrobials in the community and also use these conservatively.