EFFECT OF ATORVASTATIN AND ROSUVASTATIN ON QUORUM SENSING, BIOFILM FORMATION AND BACTERIAL MOTILITIES OF PSEUDOMONAS AERUGINOSA

Authors

  • SAJAL SARABHAI Department of Microbiology, Panjab University, Chandigarh
  • LOVEDEEP KAUR DHALIWAL Department of Microbiology, Panjab University, Chandigarh
  • NEENA CAPALASH Department of Biotechnology, Panjab University, Chandigarh
  • PRINCE SHARMA Department of Microbiology, Panjab University, Chandigarh

Keywords:

Atorvastatin /Rosuvastatin/ Biofilm/ Motilities/ Pseudomonas aeruginosa/ Quorum sensing

Abstract

Statins have been widely studied as antibacterial compounds, but the mechanism of their bacterial inhibition is still not known. In the present investigation two statins, atorvastatin and rosuvastatin, were tested for their antimicrobial activity against Pseudomonas aeruginosa and both showed MIC of 625μg/ml. Both the statins shared structural similarity with quorum sensing signal molecule of Gram negative bacteria i.e. N-acylhomoserine lactone (AHL) but showed no functional agonist or antagonist activity, as indicated by QS-deficient Agrobacterium tumefaciens A136 biosensor strain. Atorvastatin increased the flagella-mediated swarming, swimming and type IV pili-mediated twitching motilities and biofilm formation in P. aeruginosa PAO1 while rosuvastatin decreased all three motilities slightly but had no effect on biofilm formation.

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Published

31.03.2015

How to Cite

SAJAL SARABHAI, LOVEDEEP KAUR DHALIWAL, NEENA CAPALASH, & PRINCE SHARMA. (2015). EFFECT OF ATORVASTATIN AND ROSUVASTATIN ON QUORUM SENSING, BIOFILM FORMATION AND BACTERIAL MOTILITIES OF PSEUDOMONAS AERUGINOSA. International Journal of Pharma and Bio Sciences, 6(1), 1–8. Retrieved from https://ijpbs.net/index.php/journal/article/view/3956

Issue

Volume 6, Issue 1, 2015

Section

Research Articles

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