SYNTHESIS,CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF 5-SUBSTITUTED PHENYL-N-(6-(PROPYLTHIO)-1H-BENZO [D]IMIDAZOL-2-YL) -1, 3, 4-OXADIAZOL-2-AMINES

Authors

  • K.BLESSI PRIYANKA University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh,India.
  • B.SHOBARANI University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh,India.
  • G.SAMMAIAH University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh,India.

Keywords:

benzimidazole, oxadiazole, carrageenan, rat paw edema method.

Abstract

A series of  5-substituted phenyl-N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl)-1, 3, 4-oxadiazol-2-amines were prepared by treating substituted 2-benzylidene-N-(6-(propylthio)-1H-benzo[d]imidazol-2-yl) hydrazine carboxamides with Chloramine T.The newly synthesized derivatives were screened against anti-inflammatory activity using COX kit.The compounds showed dose dependent activity. The compounds which showed better in-vitro activity tested for in-vivo activity using Carrageenan rat paw edema method.

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Published

31.03.2015

How to Cite

K.BLESSI PRIYANKA, B.SHOBARANI, & G.SAMMAIAH. (2015). SYNTHESIS,CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF 5-SUBSTITUTED PHENYL-N-(6-(PROPYLTHIO)-1H-BENZO [D]IMIDAZOL-2-YL) -1, 3, 4-OXADIAZOL-2-AMINES. International Journal of Pharma and Bio Sciences, 6(1), 499–505. Retrieved from https://ijpbs.net/index.php/journal/article/view/3923

Issue

Volume 6, Issue 1, 2015

Section

Research Articles

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