PROTEIN MODELING AND DRUG DOCKING STUDIES ON ROTEIN TARGET OF EAE IUNTIMIN (E COLI)) BY BIOACTIVE ONSTITUENTS OF PHYLLANTHUS EMBLICA

Abstract

The background of the present Insilico studies, was to find out the potential protein target in   Eae  iuntimin (E coli) and deliver the 3 D structure and to find out the best inhibitors of  the   virulence protein.  Alkaloids from medicinally important plant Phyllanthus emblica (Phyllantidine and Phyllanthine) were used for the above purpose using molecular drug docking techniques. The Phyllanthine, Phyllantidine and the commercial antibiotic gentamicine potentially inhibited the target protein Eae  iuntimin (E coli)  . Based on the molecular drug docking and binding affinities of the target protein Eae  iuntimin (E coli)  it was found that the Amla alkaloid Phyllanthine showed  high binding values than Phyllantidine and the existing drug Gentamicine.