ATOMIC ABSORPTION AND ATOMIC EMISSION SPECTROMETRY FOR THE MICRO-DETERMINATION OF METFORMIN EMPLOYED IN CONTROL OF BLOOD SUGAR LEVEL IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES

Authors

  • S.KHALIL Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Taif 21944, P. O. Box 2425, KSA.Chemistry Department, Faculty of Science, Fayoum University, Egypt.
  • Y. M. HUSSEIN Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Taif 21944, P. O. Box 2425, KSA.Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt.
  • A. BUSHARA Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Taif 21944, P. O. Box 2425, KSA.Department of Chemistry, Faculty of Science, Al Dalanj University, Sudan.
  • B. RAAFAT Medical Laboratories Department, College of Applied Medical Sciences, Taif University, Taif 21944, P. O. Box 2425, KSA.Genetic Engineering and Biotechnology Division Biophysics Group, National Research Center ,Cairo, Egypt.

Keywords:

Ion associate complexes, Pharmaceutical Analysis, Atomic Emission and Atomic Absorption Spectrometry.

Abstract

Ion-associate complexes of metformin hydrochloride drug employed in control of blood sugar level  with ( manganese(II), zinc(II) and cadmium(II)) thiocyanates and ammonium reineckate  are precipitated. The solubility of the solid complexes at the recommended optimum conditions of pH and ionic strength values have been studied. Saturated solutions of each ion associate at differ­ent temperatures under the optimum precipitation conditions were prepared and the metal ion contents in the supernatant were determined. A new accurate and precise method based on direct coupled plasma atomic emission and atomic absorption spectrometry  for the determination of metformin (0.33-36.42 μg/ml) in pure solution, pharmaceutical Formulations  and in urine samples of diabetic patients type-2 in Taif  Area, Saudia Arabia is given.

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Published

31.03.2015

How to Cite

S.KHALIL, Y. M. HUSSEIN, A. BUSHARA, & B. RAAFAT. (2015). ATOMIC ABSORPTION AND ATOMIC EMISSION SPECTROMETRY FOR THE MICRO-DETERMINATION OF METFORMIN EMPLOYED IN CONTROL OF BLOOD SUGAR LEVEL IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES. International Journal of Pharma and Bio Sciences, 6(1), 226–235. Retrieved from https://ijpbs.net/index.php/journal/article/view/3893

Issue

Volume 6, Issue 1, 2015

Section

Research Articles

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