LIPID PEROXIDATION AND ANTIOXIDANTS IN ALZHEIMER’S DISEASE

Abstract

The concepts of oxidative stress and antioxidants have been implicated in neurodegenerative
disorders. Oxidative stress was assessed by estimating lipid peroxidation product in the form of
thiobarbituric acid reactive substances (TBARS). Enzymatic antioxidants like superoxide
dismutase(SOD), glutathione peroxidase(GPx), catalase, ceruloplasmin and non enzymatic
antioxidant vitamins like vitamin-E, vitamin-C were estimated in either serum or plasma or
erythrocyte in 25 patients of Alzheimer’s disease and control subjects in the age group 60-85
years. The trace elements copper, zinc and selenium were also estimated. Plasma lipid
peroxidation levels were significantly raised but activity of superoxide dismutase, glutathione
peroxidase, catalase, ceruloplasmin and levels of vitamin–E, vitamin-C, copper; zinc and selenium
were significantly reduced in Alzheimer’s disease in comparison with control subjects. Study
indicates that elevated oxidative stress and reduced antioxidant status may be playing role in
cholinergic, noradrenergic and dopaminergic cell loss and involved in pathogenesis of Alzheimer’s
disease.