CYPERMETHRIN AND SODIUM FLUORIDE SYNERGISTIC EFFECT ON OXIDATIVE ENZYMES IN MUSCLE AND KIDNEY OF ALBINO MICE

Abstract

Present study was aimed to investigate the synergistic effect of cypermethrin and sodium fluoride on
oxidative enzymes. Albino mice were treated orally with cypermethrin and sodium fluoride individually
and combination, for individual administration 1/10th LD50 of cypermethrin and sodium fluoride selected
(i.e. 8.5 mg/kg body weight and 5.6 mg/kg body weight) and for combined administration 1/20th LD50
was selected (i.e 4.25mg/kg body weight and 2.8 mg/kg body weight) for 15 days and 30 days with 48
hours intervals. It reveals significant variation in glucose-6-phosphate dehydrogenase (G6PDH),
lactate dehydrogense (LDH), succinate dehydrogenase (SDH) and glutamate dehydrogenase (GDH)
activities. Glucose-6-phosphate dehydrogenase, lactae dehydrogenase and glutamate dehydrogenase
activities were enhanced where as succinate dehydrogenase activity was decreased in muscle and
kidney tissues of experimental animals. The Changes were more pronounced in combination treated
tissues than individual treated tissues and it may be due to synergistic effect of cypermethrin and
sodium fluoride.