STUDY OF SERUM LIPID PROFILE LEVEL IN PRE-ECLAMPSIA

Abstract

The current theory suggests that in preeclampsia there is an increase in the lipid peroxidation products and leads to a decrease in the plasma antioxidants except uric acid.Along with this change in the lipid profile level leads to the pathogenesis of preeclampsia.In this context, this study was undertaken to determine the changes in plasma levels of lipid peroxide, antioxidant levels in women with preeclampsia and to investigate the effect on lipid profile. To measure the levels of serum lipid profile in pre-eclampsia in comparison with normal pregnancy. Cross sectional study consisting of 30 preeclamptic and 30 healthy pregnant women. Fasting venous blood samples were collected during antepartum period and plasma levels of  TG, TC, HDL-C, VLDL-C, and LDL-C were measured.: In the preeclamptic group, there was a significant increase in the triglyceride levels, but there were no significant changes in other lipid profile parameters. The findings of the present study are consistent with previous studies, lipid profile levels are important factors in the pathogenesis of preeclampsia. In pre-eclampsia plasma antioxidants are excessively utilized to counteract the cellular changes mediated by free radicals.