OVERVIEW ON RENAL CELL CARCINOMA

Abstract

Cancer is a disease with uncontrolled multiplication and spread within the body of abnormal
forms of the body’s own cell. Renal-Cell Carcinomas (RCC) arises from the renal epithelium and
account for about 85 percent of renal cancers accounting approximately 95000 deaths every year.
Various types of renal carcinoma are conventional or clear-cell renal-cell carcinoma, papillary renal-cell
carcinoma, oncocytoma, chromophobe renal-cell carcinoma, and collecting-duct renal-cell carcinoma.
End-stage renal disease (ESRD) increases incidence of cancer at various sites. Common symptom of
RCC is flank or abdominal pain, gross hematuria, and an abdominal mass, weight loss etc. Treatment
of RCC includes surgery, chemotherapy, immunotherapy, stem cell transplant, tumor vaccine etc.
Some molecular targeted therapies are also being used and many are under clinical trials. Diabetes,
hypertension, tobacco addiction increases the probability of RCC while the green vegetables, fruits
Ca++ supplements, vitamin E reduces the risk.