Design, Preliminary QSAR Study And Drug-Likeness Score Of Isobenzofuran Analogues

Authors

  • C. IYYAPPAN1 Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India
  • C. PRAVEEN Organic Chemistry division, Central Leather Research Institute, Chennai, India
  • K. HEMALATHA Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India
  • K. GIRIJA Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India

Keywords:

Isobenzofuran, Ligand based drug design, Selective Serotonin Reuptake Inhibitor, Citalopram, Talopram, Druglikeness

Abstract

In order to create novel antidepressants without oxidative tissue damage, less side effects and good bioavailability, structurally simple selective serotonin reuptake inhibitors with a isobenzofuran skeleton were designed based on the SAR of the target molecule - Citalopram and Talopram. As a result, designed molecules obey the Lipinski rule of 5 and also give moderate to good druglikness score. 

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Published

31.12.2010

How to Cite

C. IYYAPPAN1, C. PRAVEEN, K. HEMALATHA, & K. GIRIJA. (2010). Design, Preliminary QSAR Study And Drug-Likeness Score Of Isobenzofuran Analogues. International Journal of Pharma and Bio Sciences, 1(4), 323–329. Retrieved from https://ijpbs.net/index.php/journal/article/view/376

Issue

Volume 1, Issue 4, 2010

Section

Research Articles