ANTI-RHEUMATOID ACTIVITY OF CELL WALL CONTENTS OF LACTOCOCCUS LACTIS SUBSP. CREMORIS

Abstract

Rheumatoid arthritis(RA) is an autoimmune disease characterized by persistent synovitis, systemic inflammation, and autoantibodies. Toll like receptors (TLRs) plays an important role in the pathogenesis of RA. Probioticsare widely used in the food industry and is considered a good candidate for production of heterologous proteins for developing nutraceuticals or new live vaccine strategies.To isolate cell wall contents of Lactococcuslactis subsp. cremoris and investigate the protective effect in rheumatoid arthritis in rats.Isolation of cell wall contents of bacteria using phenol extraction.RA rat model was established by Complete Freund’s Adjuvant and Rats were treated with cell wall content as prophylactic and therapeutic treatment from day 1 to 21 and 7 to 21 respectively.The present study suggests that cell wall contents has protective activity in experimentally induced RA and the activity might be attributed to presence  of cell wall contents Lipoteichoic acid, peptidoglycans etc.