PHYSIOCHEMICAL EVALUATION OF SALT FORMS OF GABAPENTIN AND PROCESSABILITY INTO SOLID UNIT DOSAGE FORM

Abstract

Salt formation is a simple way of modifying the properties of a drug having an ionisable functional group in order to overcome some undesirable characteristics of the parent drug. An active pharmaceutical ingredient often has suboptimal physiochemical or biopharmaceutical properties that can be overcome by pairing a basic or acidic drug can be dramatically altered by salt formation. The study was design to develop different salt forms of Gabapentin which is basic in nature for its physiochemical assessment and to compare its physiochemical properties. The different acids were chose based on their pH, Solubility and category for salt formation. The prepared salt forms were characterized by pH, Solubility, Dissolution rate, Dissociation constant, Liphophilisity, DSC, XRD and FTIR. In-vitro drug release and solubility study shows increased dissolution rate and solubility as compared to the pure drug. Hydrochloride, Succinate and Tannate salt forms were used, but only Tannate salt shows improved physiochemical properties.