SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SOME NEW 2,6-DIARYLPIPERIDIN-4-ONE DERIVATIVES

Abstract

Acetic acid promoted one-pot Mannich type condensation involving long chain ketones results in the formation of 3-substituted or 3,5-disubstituted 2,6-diarylpiperidin-4-ones in moderate yields. In the absence of acetic acid, the reaction does not proceed to completion. The six member heterocyclic ring adopts a chair conformation, with equatorial disposition of all the substituents. Among the different derivatives of piperidine-4-one, derivatives containing tetrazole and semicarbazone are more potent than the alkyl derivatives against bacteria and fungi.