STUDIES ON 5-CYANOURACILS: EXPEDIENT SYNTHETIC PROTOCOL FOR SYNTHESIS OF NOVEL PYRIDO[2,3-d]PYRIMIDINE AND PYRIMIDO [4,5-d]PYRIMIDINE ANALOGS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY

Authors

  • YOGESH Y. PEDGAONKAR Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai-400019, India.
  • ARUNDHATI C. LELE Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai-400019, India.
  • NUTAN H. PALSULE DESAI Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai-400019, India.
  • MARIAM S. DEGANI Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai-400019, India.

Keywords:

Cyanouracils, pyrido[2,3-d]pyrimidine, pyrimido[4,5-d]pyrimidine, multicomponent.

Abstract

Novel, diverse pyrido [2,3-d] pyrimidine and pyrimido [4,5-d] pyrimidine analogs were synthesized by the reaction of 1,3-substituted-5-cyano uracil derivatives with appropriate nucleophile under mild conditions. Utilising 5-cyano uracil with various substitutions as a substrate leads to rapid synthesis of annulated uracils with diverse biological properties.

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Published

31.12.2014

How to Cite

YOGESH Y. PEDGAONKAR, ARUNDHATI C. LELE, NUTAN H. PALSULE DESAI, & MARIAM S. DEGANI. (2014). STUDIES ON 5-CYANOURACILS: EXPEDIENT SYNTHETIC PROTOCOL FOR SYNTHESIS OF NOVEL PYRIDO[2,3-d]PYRIMIDINE AND PYRIMIDO [4,5-d]PYRIMIDINE ANALOGS WITH POTENTIAL PHARMACOLOGICAL ACTIVITY. International Journal of Pharma and Bio Sciences, 5(4), 422–439. Retrieved from https://ijpbs.net/index.php/journal/article/view/3678

Issue

Volume 5, Issue 4, 2014

Section

Research Articles

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