IN VITRO ANTICANCER ACTIVITY OF LAMOTRIGINE AND 5-FLUOROURACIL INDIVIDUALLY AND IN COMBINATION ON HUMAN K562 AND COLO320HSR CELL LINES BY TRYPAN BLUE ASSAY

Authors

  • KATARIKONDA SUDHAKAR Department of Pharmacy (pharmacology), Vagdevi College of Pharmacy and Research Centre, Brahmadevam, Nellore, A.P, India.
  • MEDA RAMESH Department of pharmacy (pharmacology), krishna teja pharmacy college, chadalawada nagar, renigunta road tirupati, chittoor dist,A.P, India.

Keywords:

Drug resistance, Toxicity, Trypan blue, Lamotrigine, 5-Fluorouracil.

Abstract

Cancer is the leading cause of disease for high mortality all over the world. Antitumor drug resistance and side effects of antitumor drugs are the most common problems in cancer chemotherapy. It is of great importance in considering the drugs having the anticancer activity and going for the new combination of cancer therapeutics for avoiding the problems of tumor drug resistance and side effects with a new therapeutic combinations and by  lowering the dose of drugs. In the present study the anticancer activity of Lamotrigine and 5-Fluorouracil individually and in combination were determined on Colo 320HSR and K562 cell lines. And our results concluded that the both drugs individually and combination have better anticancer activity at higher concentrations.

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Published

31.12.2014

How to Cite

KATARIKONDA SUDHAKAR, & MEDA RAMESH. (2014). IN VITRO ANTICANCER ACTIVITY OF LAMOTRIGINE AND 5-FLUOROURACIL INDIVIDUALLY AND IN COMBINATION ON HUMAN K562 AND COLO320HSR CELL LINES BY TRYPAN BLUE ASSAY. International Journal of Pharma and Bio Sciences, 5(4), 387–393. Retrieved from https://ijpbs.net/index.php/journal/article/view/3673

Issue

Volume 5, Issue 4, 2014

Section

Research Articles

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