SYNTHESIS OF P38 MAP KINASE INHIBITOR ANALOGUES COMPOUNDS AND QUINOXALINONE DERIVATIVES

Abstract

This paper reports the synthesis of nitrogen containing heterocyclic compounds such as quinoxalines (5-7), imidazoles (8, 9,10,11), aminothiazole (12), aminooxazole (13), aminoimidazole (14) and  benzothiazine (17) from the reaction with unsymmetrical diketone  4, 3 and 4a respectively. The aforementioned compounds with  4-pyridyl,4-fluorophenyl groups  have different  positions in their  ring skeleton. The quinoxalinone  derivatives (19, 20) were synthesized by the reaction of  (18) with o-phenylenediamine  and 4,5-dimethyl- o-phenylenediamine respectively.