SYNTHESIS, SPECTROSCOPIC INVESTIGATION AND BIOLOGICAL EVALUATION OF SOME TRANSITION METAL COMPLEXES OF A 3-(((2-HYDROXYQUINOLIN-3-YL) METHYLENE) HYDRAZONO) INDOLIN-2-ONE

Abstract

A bishydrazone was obtained by the condensation of isatin monohydrazone with 2-hydroxyquinoline-3-carbaldehyde, which formed a series of complexes with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II). The ligand and its metal complexes were characterized on the basis of elemental analysis, conductance data, magnetic susceptibility measurements, IR, UV-Vis, mass, ¹H NMR, ESR and XRD studies. By these spectral studies it is found that Co(II), Ni(II) and Cu(II) complexes have been assigned octahedral geometry where as the Zn(II), Cd(II) and Hg(II) complexes have been assigned tetrahedral geometry. The Schiff base and its metal complexes have been screened for their in vitro antibacterial and antifungal activities by MIC method. The DNA cleavage activities of all of the complexes were studied by the agarose gel electrophoresis method. In addition, the free ligand along with its complexes has been studied for their antioxidant activity.