ANTIBACTERIAL ACTIVITY OF ANTHRAQUINONE ENCAPSULATED CHITOSAN/POLY(LACTIC ACID) NANOPARTICLES

Authors

  • JEEVITHA D Faculty of Science and Humanities (Life Sciences), 3Faculty of Bioengineering (Life Sciences), Department of Biotechnology, Sathyabama University, Rajiv Gandhi Salai, Sholinganallur, Chennai – 600119, Tamilnadu, INDIA.
  • MALATHY BR Department of Microbiology, 4Department of Biochemistry, Sathyabama University Dental College and Hospitals, Rajiv Gandhi Salai, Sholinganallur, Chennai – 600119, Tamilnadu, INDIA
  • PRADEEP PS Faculty of Bioengineering (Life Sciences), Department of Biotechnology, Sathyabama University, Rajiv Gandhi Salai, Sholinganallur, Chennai – 600119, Tamilnadu, INDIA.
  • SRIVIDYA S Department of Biochemistry, Sathyabama University Dental College and Hospitals, Rajiv Gandhi Salai, Sholinganallur, Chennai – 600119, Tamilnadu, INDIA

Keywords:

Antibacterial, Anthraquinone, Chitosan, MBC, Poly(lactic acid), Stability.

Abstract

The aim of this research is to evaluate antibacterial activities against multi drug resistance pathogens with the prepared anthraquinone (AQ) coated polymeric nanoparticles, chitosan (CS) and poly(lactic acid)(PLA) (CS/PLA-AQ NPs). The preliminary and cold stability study was determined for its drug loading capacity, encapsulation efficiency and in vitro drug release behaviour using UV spectrophotometer. The formulation (CS/PLA-AQ NPs) was tested for its antibacterial effect by disc diffusion method and Minimum bactericidal Concentration (MBC) on Gram negative bacteria’s (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus vulgaris) which was found to have higher activity when compared to CS-PLA NPs and bare AQ. The results specified that the nanoparticles formulation is a possible applicant to be considered as an antimicrobial agent in vitro.

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Published

31.12.2014

How to Cite

JEEVITHA D, MALATHY BR, PRADEEP PS, & SRIVIDYA S. (2014). ANTIBACTERIAL ACTIVITY OF ANTHRAQUINONE ENCAPSULATED CHITOSAN/POLY(LACTIC ACID) NANOPARTICLES. International Journal of Pharma and Bio Sciences, 5(4), 20–28. Retrieved from https://ijpbs.net/index.php/journal/article/view/3636

Issue

Volume 5, Issue 4, 2014

Section

Research Articles

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