ANTI-ARTHRITIC EFFECT OF 1'-ACETOXYCHAVICOL ACETATE IN COMPLETE FREUNDS ADJUVANT-INDUCED ARTHRITIS IN RATS.

Authors

  • VIJAYKUMAR M. KALE Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.
  • AJAY G.NAMDEO Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.

Keywords:

1'-Acetoxychavicol acetate, Anti-arthritic, Acetone extract of Alpinia galanga, Complete Freund’s adjuvant.

Abstract

1'-Acetoxychavicol acetate (ACA) is a phenylpropanoid present in Alpinia galanga (L) Willd syn. Languas galanga. The objective of this study was to isolate 1'-Acetoxychavicol acetate (ACA) from acetone extract of Alpinia galanga (AEAG) and evaluate anti-arthritic activity of 1'-Acetoxychavicol acetate (ACA) and acetone extract of Alpinia galanga (AEAG) on complete Freund’s Adjuvant-induced arthritis in rats. Radiographic and histopathological observations were evaluated. AEAG (400 mg/kg) and ACA (10 and 20 mg/kg) suppressed the paw swelling, increased the paw withdrawal latency, and reduced the paw thickness in arthritic rats. Radiological and histopathological characteristics in ACA (20 mg/kg) treated rats were comparable with that of diclofenac treated rats. The present study indicates that ACA and AEAG showed significant antiarthritic activity.

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Published

31.12.2014

How to Cite

VIJAYKUMAR M. KALE, & AJAY G.NAMDEO. (2014). ANTI-ARTHRITIC EFFECT OF 1’-ACETOXYCHAVICOL ACETATE IN COMPLETE FREUNDS ADJUVANT-INDUCED ARTHRITIS IN RATS. International Journal of Pharma and Bio Sciences, 5(4), 9–19. Retrieved from https://ijpbs.net/index.php/journal/article/view/3634

Issue

Volume 5, Issue 4, 2014

Section

Research Articles

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