IMMUNOPROTEOMICS APPROACH FOR SYNTHETIC VACCINE DEVELOPMENT FORM STREPTOCOCCUS DYSGALACTIAE SUBSP. EQUISIMILIS

Authors

  • GOMASE V.S. School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413531, MS, India
  • CHITLANGE N.R. School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413531, MS, India

Keywords:

Antigen protein, epitope, PSSM, SVM, MHC, peptide vaccine

Abstract

Streptococcus dysgalactiae subsp. equisimilis are the causative organisms of infections with Betahemolytic
group C and G streptococci. Peptide fragments of antigen protein can be used to select
nonamers for use in rational vaccine design and to increase the understanding of roles of the immune
system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from
Streptococcus dysgalactiae are important determinant for protection of host form bacterial infection. In
this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of
bacterial protein having 200 amino acids, which shows 192 nonamers. Binding ability prediction of
antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in
vaccine development from Streptococcus dysgalactiae.

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Published

30.09.2010

How to Cite

GOMASE V.S., & CHITLANGE N.R. (2010). IMMUNOPROTEOMICS APPROACH FOR SYNTHETIC VACCINE DEVELOPMENT FORM STREPTOCOCCUS DYSGALACTIAE SUBSP. EQUISIMILIS. International Journal of Pharma and Bio Sciences, 1(3), 1–6. Retrieved from https://ijpbs.net/index.php/journal/article/view/363

Issue

Volume 1, Issue 3, 2010

Section

Research Articles